Sildenafil Citrate is the chemical ingredient used in Viagra, a wonder drug for men suffering from erectile dysfunction. Men suffering from erectile dysfunction (ED) are unable to obtain or hold on an erection during sexual intercourse for the desired results. An adequate amount of blood flow with the required sexual stimulation is the key to achieve erection in men. As such, a men suffering from erectile dysfunction does not obtain the required blood flow in his penis.
With adequate sexual stimulation, Nitric Oxide (NO) is released in the corpus cavernosum of the penis. Nitric Oxide binds with the receptors of an enzyme called guanylate cyclase. This increases the level of cGMP (cyclic guanosine monophosphate) resulting in a widening of the blood vessels of the penis. This mechanism leads to the increase in blood flow of the penis resulting in an erection.
As understood from above, cGMP (cyclic guanosine monophosphate) is important for the increase in blood flow to the penis. PDE5 (Phosphodiesterase type 5) degenerates cGMP in the corpus cavernous. As one might easily guess, PDE5 is what restricts the blood flow and prevents the erection.
Sildenafil keeps cGMP from degradation by PDE5 as it is an efficient inhibitor of PDE5. The molecular arrangement of Sildenafil is similar to that of cGMP hence it readily binds with PDE5 instead of cGMP resulting in a hard rock erection.
Long story short, Sildenafil prevents cGMP from getting hydrolyzed by PDE5 into inactive GMP.
For the desired results, take the pills orally 30 to 60 minutes prior to sexual intercourse. Taking the pills alone does not guarantees an erection without sexual stimulation. The pills should never be consumed twice in 24 hours. High-fat meals delay the onset of the results of the medication. If the medication still doesn’t works for you, don’t be disheartened you can always switch to higher dosage or other alternates of Sildenafil like Tadalafil, Vardenafil or Super P Force . Consult your doctor to determine the right dosage for you.